Cannabis and Naproxen (e.g. Aleve, Naprosyn, Proxen, Naprux)

Exploring the potential interactions between various medications and cannabis is crucial in this age of increased cannabis use and legalization. In this article, we shine a light specifically on the interactions between cannabis and naproxen – a common nonsteroidal anti-inflammatory drug (NSAID). It’s important to note that while this article aims to provide an evidence-based overview, it should not be used as personal medical advice. Always consult with healthcare providers to get personalized recommendations and advice.

2. Overview of Cannabis

Components

Cannabis is a plant that contains a number of active components, most notably delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is primarily responsible for the psychoactive effects – or the ‘high’ – associated with cannabis use. On the other hand, CBD does not have psychoactive effects and is often used for medicinal purposes for its potential therapeutic effects, such as reducing anxiety and inflammation.source

Common Uses

Cannabis is used both recreationally and medicinally. Recreational use often seeks the psychoactive effects, while medicinal use leverages the potential therapeutic effects of cannabis – which can be particularly useful in managing chronic pain, nausea from chemotherapy, and certain symptoms of multiple sclerosis.source

3. Overview of the Pharmacological Drug

Drug Information

Naproxen is a type of nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body.source

Common Uses

Naproxen is typically prescribed for relief from various conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. It is also used to treat acute pain and headaches.source

4. Potential Interactions

Physiological Basis

Both naproxen and cannabis are metabolized in the liver, and there is a potential that cannabis use could affect the metabolism of naproxen. Settings where both substances are present could competitively inhibit metabolic pathways, potentially leading to higher levels of naproxen in the body.source

Research Findings

Research on the interaction between cannabis and naproxen specifically is lacking. However, cannabis has been found to interact with other NSAIDs, possibly affecting their metabolism and efficacy.source

5. Risks and Warnings

Adverse Effects

The most common risk when combining cannabis with naproxen would be stomach upset, including ulcers or bleeding, which can be exacerbated by the presence of both substances. Additionally, some patients may experience drowsiness, dizziness, and impaired motor coordination.source

Risk Populations

People who are elderly, pregnant, breastfeeding, or have other underlying medical conditions like heart disease, stomach ulcers or bleeding type disorder may be at higher risk of complications when combining cannabis with naproxen.source

6. Recommendations

Medical Advice

Always consult your healthcare provider before starting, stopping, or combining any medications or supplements, including cannabis.

Monitoring

If combined use is approved by a healthcare provider, monitor closely for any adverse effects like stomach upset, drowsiness, and dizziness.

Dosage Considerations

There may be necessary adjustments to the dosage of naproxen for those who are also using cannabis. Again, it’s key to consult with a healthcare provider for personalized advice.

7. Conclusion

Navigating the world of potential drug interactions can be complex. While research is ongoing, the potential interaction between cannabis and naproxen is an area that needs further attention. Always consult with a healthcare provider before combining medications or supplements, monitor for possible adverse effects, and stay proactive in your health management.

8. References and Further Reading

1. CDC – What is Marijuana? 2. FDA and Cannabis: Research and Drug Approval Process 3. MedlinePlus – Naproxen 4. Potential Clinical Implications of Drug-Drug Interactions with Cannabis 5. Cannabis and Its Interactions with Other Drugs 6. The Health Effects of Cannabis and Cannabis-Derived Products 7. Cannabis: An Overview of its Adverse Acute and Chronic Effects and its Implications

Read about cannabis and alternative pain relievers

• Aspirin
• Ibuprofen
• Paracetamol
• Naproxen
• Metamizole